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Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. This is because DTIT-guidance allows closer and more consistent placement of leads to the centre of the DRTT than conventional methods. Speech problems were more common in Group A patients.ĭTIT-guided lead placement results in better and more stable tremor control and fewer adverse effects compared to lead placement in the conventional manner. The active contacts of Group B patients were consistently closer to the centre of the DRTT than in Group A. The better outcomes were sustained for up to 60-months from surgery. However, Group B patients had significantly better arm tremor control (especially control of intention tremor), increased mobility and activities of daily living, reduced social stigma and need for social support as well as lower stimulation amplitudes and pulse widths compared to Group A patients. PSA-DBS resulted in marked tremor reduction in both groups. Tremor (Fahn-Tolosa-Marin) and quality-of-life (PDQ-39) scores were evaluated 0-, 6-, 12-, 36- and 60-months after surgery. Patients were randomised to Group A (DBS leads inserted using conventional landmarks) or Group B (leads guided into the DRTT using DTIT). To compare posterior subthalamic area deep brain stimulation (PSA-DBS) performed in the conventional manner against diffusion tensor imaging and tractography (DTIT)-guided lead implantation into the dentatorubrothalamic tract (DRTT).ĭouble-blind, randomised study involving 34 patients with either tremor-dominant Parkinson's disease or essential tremor.